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      • Science & Mathematics
        January 2020

        Inverse Coordination Chemistry

        A Novel Chemical Concept

        by Ionel Haiduc, Edward R.T. Tiekink

        Inverse Coordination Chemistry: A Novel Chemical Concept features and discusses the interesting array of inverse coordination complexes, from those with monoatomic or polyatomic centres to those with organic molecules as centres. While traditional coordination complexes consist of a metal atom at the centre surrounded by inorganic ligands, inverse coordination complexes show a reversed topology: a central non-metal atom surrounded by metallic ligands.   Concisely written and with full-coloured illustrations, this book is a timely and comprehensive introduction to this exciting but largely overlooked field of inverse coordination in inorganic chemistry. This book serves as an invaluable resource for chemists, educators, and students.   Click here for more information

      • Science & Mathematics
        March 2021

        Lady Ranelagh

        The Incomparable Life of Robert Boyle's Sister

        by DiMeo, Michelle

        For centuries, historians have speculated about the life of Katherine Jones, Lady Ranelagh. The details of her relationship with Robert Boyle, her younger brother, have mostly remained a mystery, even though Boyle, “the father of chemistry,” spent the last twenty-three years of his life residing in her home, with the two dying only one week apart in 1691. The dominant depiction of Lady Ranelagh shows her as a maternal figure to Boyle or as a patroness of European intellectuals of the Hartlib circle. Yet neither of these portraits captures the depth of her intellect or range of her knowledge and influence. Philosophers, mathematicians, and religious authorities sought her opinion on everything from decimalizing the currency to producing Hebrew grammars. Lady Ranelagh practiced medicine alongside distinguished male physicians, treating some of the most elite patients in London, and her medical recipes and testimony concerning the philosophers’ stone both gained international circulation. She was an important influence on Boyle and a self-standing historical figure in her own right. Chemistry’s Sister fills out Lady Ranelagh’s legacy in the context of a historically sensitive and nuanced interpretation of gender, science, and religion. It reveals how one elite seventeenth-century woman, without suffering attacks on her “modesty,” managed to gain the respect of diverse contemporaries, effect social change, and shape science for centuries to come.

      • Mineralogy & gems
        September 2021

        Quasicrystals

        The Adventure of a Discovery

        by Luca Bindi

        A fragment of popular science drawing attention to an extraordinary discovery: the experimental proof on the existence of quasicrystals in nature. A physical, human, and scientific journey, which starts from Italy, crosses the US, reaches the Russian Far East and winks at space.

      • Chemistry
        October 2013

        In Silico Drug Discovery and Design

        by Markus A Lill

        Computational methods have now evolved into sophisticated tools that are routinely used in industry and academia to develop and design drugs. The fifteen chapters of this book summarize the current status and recent developments in computer-aided drug-design methodology. The book is organized into four sections, with the first dedicated to current methods for identifying potential hits for target proteins and predicting the binding affinity between protein and ligands. The second section focuses on recent developments in ligand-based drug design methods, particularly those methods based on identifying similarities among known active compounds for use in predicting novel actives or scaffolds. The third section extends discussion toward the prediction of pharmacokinetic properties such as absorption, distribution, metabolism, excretion and toxicity of drugs. In the final section, some emerging trends in computer-aided drug-discovery are presented. The book provides a concise overview of current and emerging computer-aided drug-discovery technologies, including their successes and limitations, for developers and practitioners. It will also interest students eager to enter this exciting, highly interdisciplinary field of research.

      • Chemistry
        October 2013

        An Introduction to Green Chemistry Methods

        by Rafael Luque, Juan Carlos Colmenares

        This overview of the most important and relevant topics in green chemical methodologies is organized into eleven concise chapters, authored by leading international scientists. Among the topics covered in the book are fundamentals and metrics, solvent-free synthesis, green catalysis, biomass pyrolysis, biofuel production, CO² capture and recycling of fuels and materials, and green chemistry principles for depollution. The book will interest students, scientists and experienced practitioners/industrialists as a rounded introduction to green chemistry.

      • Chemistry
        February 2014

        Advances in Collating and Using Trial Data

        by Sylvie Chevret, Matthieu Resche-Rigon

        Clinical trials remain a cornerstone in the development of medical guidelines and in health policy decision-making. Data provide the foundations of all good clinical research, and advances in collating and using trial data are therefore of prime interest in establishing high-quality clinical research. The increasing use of electronic media, network technologies and powerful computation in the collection and analysis of data can lead to improvements in terms of cost, timelines and capabilities, and also facilitate new trial designs based on social networks, for example, or access to large patient databases. This book presents several new aspects in the management of trial data from the collection to the analysis, including ethical concerns.

      • Chemistry
        October 2013

        Important considerations for clinical trial methodologies

        by Vance W Berger, Xiao (Cathy) Zhang

        This compilation of nine chapters provides an expert overview of methodology and design in clinical trials and addresses the challenges of controversies and abuses in medical research. Each chapter is fully referenced, so that the interested reader can easily learn more about any of the fascinating topics addressed. The book provides a useful resource for professionals engaged in clinical trials and a valuable introduction for those new to the field. It could also serve as a valuable textbook for a class in special topics in clinical trial design and analysis.

      • Chemistry
        October 2013

        Recent progress and new developments in post-combustion carbon-capture technology with reactive solvents

        by Paitoon Tontiwachwuthikul, Raphael Idem

        Globally, the capture of CO2 from industrial flue gases has become a critical environmental issue; therefore, the need for R&D in cost-effective CO2 capture technologies is urgent. Currently, post-combustion carbon capture is the only industrial carbon emission management technology that is ready for commercialization and wide-scale deployment. The purpose of this book is to provide designers and operators of amine solvent-based CO2 capture plants with a comprehensive guide to the fundamental chemistry and physics of CO2 capture plant operation. This book is the culmination of more than 20 years of fundamental research on amine solvents and their application to carbon capture, and the technologies and research results described in this book represent some of the leading carbon-capture technologies in the world to date. Overall, this book provides both the theoretical basis of plant operation in terms of thermodynamics, transport phenomena, chemical reaction kinetics/engineering, membrane separation, interfacial phenomena and materials, and will be of great value to engineers, scientists and decision-makers working in academia, industry and government.

      • Chemistry
        October 2013

        Forensic drug analysis

        by Olaf Drummer, Dimitri Gerostamoulos

        Forensic drug testing brings together multiple related disciplines toward the detection and identification of drugs and poisons, together with interpretation of the findings, for medico-legal purposes. Laboratories conducting such testing should have certification or accreditation and the forensic drug analysts require a high degree of competency. This ten chapter book provides a thorough overview of the field, addressing issues such as collection of evidence, pre-analytical issues, types of substances, strategies and techniques in analysis and interpretation of data.

      • Chemistry
        October 2013

        Molecular Imaging Techniques: New Frontiers

        by Florence Gazeau

        The principal objective of molecular imaging in the context of more individualized approaches in medicine is to develop efficient ways to diagnose disease and monitor therapy in patients. In twelve chapters, this multi-author book reviews key advances achieved in the techniques of such molecular imaging. The chapters are mainly organized according to the different methods available, such as nuclear methods, MRI, optical imaging, ultrasound and electron paramagnetic resonance, and for each imaging modality, different biological targets are tackled. The book illustrates how molecular imaging has enormous relevance for preclinical and clinical practice, and how, by revealing both the clinical biology of the disease process and the mechanisms of the treatment, it has the potential to personalize patient care.

      • Chemistry
        November 2013

        Nucleic Acid-Based Drugs

        by Jonathan P Wong

        There is renewed optimism regarding the future of clinical development of nucleic acid-based drugs. This ninechapter overview addresses this field in two segments: the first part is focused on the fundamental essence of scientific knowledge and insights in the field, while the second segment highlights the potential therapeutic applications of nucleic acidbased drugs. The book concludes commentary on the future trends and landscape of nucleic acidbased drug development in clinical medicine.

      • Chemistry
        October 2013

        Therapeutic Delivery Methods: A Concise Overview of Emerging Areas

        by Beom-Jin Lee

        In recent years, pharmaceutical research has focused on delivering pharmaceuticals that achieve rapid and effective treatment of diseases or targeting of disease sites. This book provides a concise overview of emerging areas of therapeutic delivery methodology for readers who have preliminary backgrounds in pharmaceutical sciences, drug delivery or formulation. The ten chapters reflect the multidisciplinary nature of the emerging research into therapeutic-based drug-delivery systems and provide a valuable resource for pharmaceutical scientists and all those involved in the research and development in drug formulation, dosage form design and drug delivery for therapeutic goals.

      • Analytical chemistry
        January 2014

        Global Metabolic Profiling: Clinical Applications

        by Ian D Wilson, Georgios Theodoridis, Andrew Nicholls

        The aim of many current global metabolic profiling studies is to discover and apply new metabolic biomarkers. These may be indicative of the mechanisms of disease or the propensity for it to develop, or may enable diagnosis, patient stratification, and prediction/monitoring of response to therapy. The use of global metabolic profiling in the clinic in the future seems assured, and it seems likely that future application will include novel innovations that will put metabolic profiling into the doctor’s consulting room or even into the hands of the surgeon in the operating theatre. The twelve chapters of this timely book provide a snapshot of the current state of the art in metabolic profiling in the clinic.

      • Chemistry
        November 2013

        Biosensors and Their Application in Healthcare

        by Dilsat Ozkan-Ariksoysal

        Biological sensors are optical, electrical, piezoelectrical devices that have the ability to detect biological compounds, such as nucleic acids and proteins. The need for rapid, simple hand-held testing devices in medicine has driven a strong interest in biosensor development for clinical purposes in recent years. In this eight-chapter work, international experts share their valuable studies in the area of biosensors to provide a state-of-the-art overview to inform and inspire researchers at all levels.

      • Chemistry
        October 2013

        Tissue Analysis for Drug Development

        by Stacy Ho

        Tissue analysis plays an important role in drug discovery and development. The purpose of tissue analysis varies depending on the type and stage of the drug discovery and development, and there is no one-size-fit-all solution. In the six chapters of this book, the authors highlight the critical aspects and considerations of tissue analysis. They summarize the general principles and processes in tissue analysis with useful and practical information so that the reader is then able to identify the critical factors and address their own particular challenges. This timely compilation describes the typical methodologies and current practices of tissue analysis in drug development, together with some case studies. It is intended for researchers who have a general knowledge of bioanalysis but may or may not have extensive exposure of tissue analysis, and is also relevant to researchers in other fields, such as environmental monitoring and food testing.

      • Chemistry
        February 2014

        Hot Topics in Biomaterials

        by Ifty Ahmed

        In recent years, huge advances have been made in the development of novel biomedical materials, and research in this field today is truly a multidisciplinary arena. The expert coverage of the eight chapters in this book reflects the diverse nature of the field of biomaterials science and encompasses contributions from a wide range of fields, highlighting key classes of novel materials and exploring the underlying science and potential applications. The book will aid understanding of novel materials, biological methods and systems in order to maximize full potential of future developments.

      • Analytical chemistry
        October 2013

        Bioanalysis of Biotherapeutics

        by Boris Gorovits

        The pharmaceutical industry has recently introduced a number of biotherapeutics with alternative types of scaffolds and mechanisms of action. Concepts that were proposed several years or, in some cases, decades ago are starting to become a reality, with a number of new and exciting compounds achieving regulatory approval status. As the field evolves, appropriate bioanalytical applications must be developed and adapted. Highly sensitive, accurate and specific bioanalytical methods are now required to measure drug concentration and immunogenicity responses, and bioanalytical protocols must undergo formal validation prior to being applied in support of regulated nonclinical or clinical studies. The six chapters of this book introduce important and exciting challenges for the bioanalysis of peptides, oligonucleotides, antibody–drug conjugates and antibody-based compounds.

      • Analytical chemistry
        October 2013

        Bioanalysis for Service Users

        by Anne-Francoise Aubry, Jim X Shen

        This book provides an important reference resource for users of bioanalytical services and will be helpful to nonexperts who need to interpret bioanalytical data or outsource bioanalytical assays. The eight chapters address many of the difficult issues and challenges in bioanalysis together with the capabilities, applications, advantages and limitations of the main technological platforms utilized. Validation principles and the experimental approaches used to establish validation parameters are explained, as well as the regulatory expectations regarding assay performance during routine sample analysis. Some guidance regarding outsourcing of bioanalytical assays and common assay performance issues and pitfalls is provided to help readers interact more knowledgeably with bioanalytical scientists and better follow investigations in the bioanalytical laboratory.

      • Analytical chemistry
        November 2013

        Immunogenicity Assay Development, Validation and Implementation

        by Robert Dodge, Renuka C Pillutla

        In recent years there have been significant improvements and standardization in immunogenicity testing and the reporting of results. Technology developments and responses to increasing regulatory expectations have enabled the development of superior bioanalytical methods. In nine chapters from international experts, this book provides an excellent overview, with detailed summaries of advances in testing schemes. Critical topics include reagents used in assays, a summary of techniques used in overcoming assay interferences and considerations in statistical evaluation. Overviews of neutralizing antibody assays are presented together with an overview of regulatory guidance and recommended procedures.

      • Analytical chemistry
        December 2013

        Hot topics in Metabolomics: Food and Nutrition

        by Bernd Markus Lange

        Metabolomics is an emerging technology aimed at providing comprehensive profiles of small-molecule metabolites accumulated in microbes, plants and animals, or in food products derived from these organisms. In this book, experts in the field have contributed eight chapters reviewing the current status of the use of metabolomics in the food and nutritional sciences. Three areas of research are addressed – first, integration of metabolomics into crop improvement programs based upon classical breeding or genetic engineering; second, the role of metabolomics in food quality control, including authentication, safety, predictive modeling of sensory and nutritional attributes, and the analysis of processed foods; finally, the utility of metabolomics in assessing the correlation of dietary composition and human health. Technological advances are continually increasing the utility of metabolomics, and food and nutritional enterprises have much to gain from integrating this technology across the different sectors.

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