After chemistry, the origins of biochemistry began at the end of the 19th century. The first major step was made when glycated hemoglobin, HbA1c, was found to be a precious index to follow an adapted antidiabetic treatment.
This discovery led to the identification of cell receptors, present in vascular cells, leukocytes, neuronal cells. One such cell receptor, RAGE, has been shown to be a major contributor in cell alteration, the development of vascular complications in diabetes mellitus, ageing, and Alzheimer’s disease.
This book shows that the axis AGE-RAGE and the activation of RAGE by other ligands open up a possible new therapeutic approach to prevent complications of diabetes mellitus and ageing. As such, it will particularly appeal to chemists, biochemists, biologists, immunologists, nutritionists, doctors, cardiologists, and neurologists.
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Jean-Luc Wautier, MD, PhD, has been the Professor of Hematology at the University of Paris since 1986 and has served as Director of the Laboratory of Cellular Biology. He is the author of over three hundred research articles in various prestigious and specialized journals, including The New England Journal of Medicine, Lancet, Journal of Clinical Investigation, and Blood. He has received numerous awards for his research, including the Mémain-Pelletier Prize, the most prestigious prize from the French National Academy of Sciences. His research has led to the understanding of why high blood sugar levels in people with diabetes can cause the hardening of arteries and blood vessels which leads to blindness, kidney failure and heart disease.